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(Investigative Ophthalmology and Visual Science. 1962;1:95-100.)
© 1962 by The Association for Research in Vision and Ophthalmology, Inc.

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The Effect of Ionizing Radiation on Protein and Carbohydrate Metabolism in the rat Lens

SIDNEY LERMAN 1, ANIMA DEVI 1, and RENAKA BANERJEE 1

1 Department of Surgery, Division of Ophthalmology, University of Rochester School of Medicine and Dentistry.

The effects of ionizing radiation on the rat lens were investigated by means of single 1,500 r whole body or head exposures. The results indicate that there is no marked alteration in carbohydrate metabolism within the first week or two after such exposures to x-ray. A marked increase in the incorporation of C-14-leucine only into the insoluble protein-RNA complex of such lenses has been shown to occur within 6 hours after irradiation. A similar increase in the incorporation of P-32 into this albuminoid RNA° also becomes manifest 6 hours after exposure to x-ray.






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