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(Investigative Ophthalmology and Visual Science. 1962;1:561-564.)
© 1962 by The Association for Research in Vision and Ophthalmology, Inc.

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Therapy of Experimental Herpes Simplex Keratitis

HERBERT E. KAUFMAN 1 and GEORGE M. HOWARD 2

1 Massachusetts Eye and Ear Infirmary, Boston, Mass.; Present address, J. Hillis Miller Health Center, University of Florida, Gainesville, Fla.
2 Massachusetts Eye and Ear Infirmary Boston, Mass.

Topical therapy with trypsin, chymotrypsin, and monoxychloroserene, and corneal scrub with iodine, ether, and silver nitrate did not demonstrably reduce the incidence of a positive virus culture from rabbit corneas infected with herpes simplex. It is suggested that the virucidal properties of such substances as measured by their effect on cell-free virus suspensions is not pertinent to the abolition of infection from primary experimental dendritic keratitis, and may not be an important consideration in the therapy of this condition.






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