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(Investigative Ophthalmology and Visual Science. 1962;1:666-671.)
© 1962 by The Association for Research in Vision and Ophthalmology, Inc.

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Effects of Triethylenethiophosphoramide on the Carrageenin Granuloma of the Guinea Pig Cornea

ROBERT P. BURNS 1 and RICHARD BEIGHLE 2

1 John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore.
2 John E. Weeks Institute for the Advancement of Ophthalmology, University of Oregon Medical School, Portland, Ore.; Recipient of Fight-for.Sight Summer Student Fellowship, SF 187 (C2), from the National Council to Combat Blindness, Inc., New York, N. Y.

The carrageenin granuloma of the guinea pig cornea is an excellent tool to use in controlled study of new therapeutic agents. In vascularization of the guinea pig cornea induced by the carrageenin granuloma, selected levels of dosage of triethylenethiophosphoramide applied, locally or subconjunctivally were found to inhibit growth of blood vessels into the cornea. This inhibition of vascularization was only temporary and was accompanied by prolongation of corneal opacity and toxic side effects.






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