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(Investigative Ophthalmology and Visual Science. 1962;1:712-727.)
© 1962 by The Association for Research in Vision and Ophthalmology, Inc.

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The Mode of Action of Pilocarpine on Outflow Resistance in the Eye Primate (Cercopithecus Ethiops)

ERNST H. BÁRÁNY 1

1 Department of Physiology, School of Medicine, Makerere College Kampala, Uganda Department of Pharmacology, University of Uppsala Sweden.(permanent address of author).

Facility of outflow in the eye of the vervet monkey Cercopithecus ethiops ivas studied by constant-rate and by constant-pressure infusion. Facility increased greatly after the injection of 2 to 3 mg of pilocarpine into the anterior chamber or after the application of 0.2 to 0.3 mg. to the cornea. The effect on facility consisted of 2 components. One component was reversed in 3 to 5 minutes by 1 mg. per kilogram intravenous atropine, the time it took for the atropine to relax pilocarpine-induced accommodation. The other component was reversed only slowly by intravenous or even intracameral atropine. The slowly reversed component teas thought to represent a pilocarpine action directly on the endothelial cells of the outflow system, possibly a histamine-like action on the endothelial wall of Schlemm's canal.




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