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(Investigative Ophthalmology and Visual Science. 1962;1:751-755.)
© 1962 by The Association for Research in Vision and Ophthalmology, Inc.

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The Effects of Cortisone on Pine Pollen-induced uveitis in Guinea Pigs

STAN L. COLEMAN 1 and SAMUEL CANAAN 1

1 Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.

Injection of pine pollen into the vitreous of guinea pigs previously sensitized with Freund's adjuvant and pine pollen intradermally and intraperitoneally restdted in a dissemimited granulomatous inflammatory process involving the entire uveal tract. Moderate or large doses of steroids (2 to 8 mg. per kilogram per day of prednisolone) diminished the reaction when given 1 to 2 weeks after the challenge, but caused an increase in severity of the reaction if given during the period of sensitization or immediately after the challenge.






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