IOVS Health Education Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 1971;10:760-769.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KNOPF, H. L.
Right arrow Articles by WONG, V. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KNOPF, H. L.
Right arrow Articles by WONG, V. G.

Antibody in Tears Following Intranasal Vaccination With Inactivated Virus

III. Role of Tear and Serum Antibody in Experimental Vaccinia Conjunctivitis

HARRY L. KNOPF 1, NEIL R. BLACKLOW 1, MORRIS I. GLASSMAN 1, WALTER L. CLINE 1, and VERNON G. WONG 1

1 Laboratory of Vision Research, National Eye Institute, National Institute of Allergy and Infectious Diseases, and National Cancer Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014

Fifteen rabbits were vaccinated with inactivated or live vaccinia virus by the intranasal or intradermal route, and then one eye was challenged with homologous lice virus. Two unvaccinated animals were similarly challenged and were used as controls. The animals were examined for clinical illness, virus shedding, and serologic changes in tears and serum. The results showed: (1) All animals shed vaccinia virus for at least one day. (2) Vaccination by any route resulted in decreased illness and virus shedding. (3) Animals with serum neutralizing antibody titers of ≥1/575 had the mildest illness by all parameters. (4) Tear antibody had no apparent effect on the illness or virus shedding. The importance of local mechanisms of protection and the application of this work to human conjunctival infections are discussed.

Key Words: vaccinia virus • formalin inactivation • tear antibody • live virus challenge • experimental conjunctivitis • immunological mechanisms • delayed hypersensitivity • neutralizing antibody

Submitted on July 15, 1971
Accepted on August 3, 1971






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1971 by the Association for Research in Vision and Ophthalmology