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(Investigative Ophthalmology and Visual Science. 1971;10:770-774.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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Lymphocyte-Stimulating Activity of Ocular Tissues in Sympathetic Ophthalmia

GEORGE E. MARAK Jr. 1, RAMON L. FONT 1, MERRILL C. JOHNSON 1, and F. PAUL ALEPA 1

1 Divisions of Ophthalmology and Rheumatic Diseases, Georgetown University Hospital, Ophthalmic Pathology Branch, Armed Forces Institute of Pathology, and Division of Nuclear Medicine, Walter Reed Army Institute of Research, Washington, D. C.

Blastogenic activity of ocular tissue extracts was elicited in lymphocyte cultures from peripheral blood of two of four patients with sympathetic ophthalmia. Retinal pigment epithelium, retina, and lens were mitogenic, while choroidal antigen was usually inactive. There was no evidence of cellular hypersensitivity to ocular tissue in several other forms of uveitis. The problems in interpreting these observations are discussed.

Key Words: Autoimmune uveitis • cellular hypersensitivity • lymphocyte transformation • sympathetic ophthalmia • uveitis

Submitted on June 11, 1971
Accepted on August 23, 1971




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Br. J. Ophthalmol., March 1, 2000; 84(3): 259 - 263.
[Abstract] [Full Text]


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