IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 1971;10:775-783.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HALL, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HALL, J. M.

Specificity of Antibody Formation after Intravitreal Immunization With Bovine Gamma Globulin and Ovalbumin

I. Primary Response

JOAN M. HALL 1

1 Francis I. Proctor Foundation for Research in Ophthalmology, University of California San Francisco, San Francisco, Calif.

Rabbits were immunized intravitreally with bovine gamma globulin in one eye and ovalbumin in the other. Uveal tract cells of a given eye produced antibody only to the antigen with which the eye had been injected. Cells from the draining lymph node produced antibody almost exclusively to the antigen injected into the eye drained by that node. When both antigens were injected into the same eye, uveal tract and lymph node cells produced antibody to both antigens. No antibodies were produced by cells from the uninjected eye. Circulating hemolysins and hemagglutinins to both antigens were demonstrated in all rabbits. Antibody was also detected in the aqueous humor. The response in the lymph nodes of rabbits that received the two antigens via the footpad teas not specific.

Key Words: hemolytic antibody • plaque-forming cells • intravitreal injection • bovine gamma • globulin • ovalbumin • uveal tract • lymphoid cells • specificity • aqueous antibody

Submitted on July 14, 1971
Accepted on August 6, 1971






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1971 by the Association for Research in Vision and Ophthalmology