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(Investigative Ophthalmology and Visual Science. 1971;10:898-903.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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Glycosidases of the Crystalline Lens

II. Alterations in Diabetic Cataracts

RICHARD CARLIN 1 and EDWARD COTLIER 1

1 Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, University of Illinois at the Medical Center, Chicago, Ill.

Six glycosidases were determined in: (1) lenses of alloxan-diabetic rats; (2) rabbit lenses incubated in high-glucose media in vitro; and (3) human senile cataracts, diabetic senile cataracts, and autopsy lenses. In diabetic rat lenses, the activities of {beta}-glucosaminidase, {beta}-galactosidase, and {beta}-fucosidase increased with cataract progression as compared to control lenses. Glycosidase activities, however, did not differ in human diabetic cataracts (patients with normal blood glucose levels) as compared to human senile cataracts or autopsy lenses. Incubation of rabbit lenses in high-glucose Tyrode's media did not affect the glycosidase activities as compared to rabbit lenses incubated in normal Tyrode's media.

Key Words: Glycosidases • crystalline lens • diabetic cataracts • {beta}-glucosaminidase • {beta}-galactosidase • {beta}-fucosidase • {alpha}-mannosidase • {beta}-glucosidase • {beta}-galactosaminidase

Submitted on June 30, 1971
Accepted on September 21, 1971






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Copyright © 1971 by the Association for Research in Vision and Ophthalmology