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(Investigative Ophthalmology and Visual Science. 1971;10:120-143.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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Anterior Segment Chemical Sympathectomy by 6-Hydroxy-Dopamine

I. Effect on Intraocular Pressure and Facility of Outflow

MONTE G. HOLLAND 1 and JAMES L. MINIS III 1

1 Department of Ophthalmology, Tulane University School of Medicine, New Orleans, La.

Histofluorometric techniques have confirmed that topical ocular application of 6-hydroxydopamine, a norepinephrine congener, causes a selective and reversible destruction of sympathetic nerve terminals in the anterior segment. An investigation of the effects of "chemical sympathectomy" on the pupil, intraocular pressure, and facility of outflow showed: the pupil underwent a sequence of changes characteristic of surgical sympathetic denervation, but with a different time course; the intraocular pressure .was significantly lowered, transiently in rabbits and of longer duration in monkeys; the facility of outflow was transiently increased in monkeys and probably in rabbits; the episcleral venous pressure was unchanged in both species. It was concluded that the lowered intraocular pressure and lowered outflow pressure were the result of a reduction of aqueous inflow. There was no unequivocal experimental demonstration of supersensitization to topical norepinephrine or isoproterenol following chemical sympathetic denervation; however, the experiments were not conclusive on this important point. It was concluded that chemical sympathectomy with 6-hydroxy-dopamine reproduces many of the ocular phenomena of surgical sympathectomy. 6-Hydroxy-dopamine is a useful drug for experimental ophthalmology, and may be useful clinically.

Key Words: chemical sympathectomy • surgical sympathectomy • 6-hydroxy-dopamine • sympathetic denervation effects • denervation supersensitization • intraocular pressure • facility of outflow • episcleral venous pressure • norepinephrine

Submitted on October 6, 1970
Accepted on December 18, 1970






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