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(Investigative Ophthalmology and Visual Science. 1971;10:151-156.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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Effect of Essential Fatty Acid Deficiency on the Fatty Acid Composition, Morphology, and Electroretinographic Response of the Retina

SIDNEY FUTTERMAN 1, JOHN L. DOWNER 1, and ANITA HENDRICKSON 1

1 Department of Ophthalmology, University of Washington Medical School, Seattle, Wash.

Essential fatty acid deficiency has been produced in rats without superimposing a deficiency of vitamin A. The fatty acid composition of normal and deficient rat tissues was determined. Retina and brain were much less changed in composition by essential fatty acid deficiency than other tissues. The electroretinographic response was only slightly altered. A loss of mural cells from the retinal capillaries was the only morphologic change observed.

Key Words: essential fatty acids • retinal capillaries • vitamin A • diabetes mellitus • electroretinogram

Submitted on October 6, 1970
Accepted on December 18, 1970




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