IOVS Drug Metabolism and Disposition
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(Investigative Ophthalmology and Visual Science. 1971;10:266-269.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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The Effect of Salicylates on Aqueous Fibrinolysin

JUDSON P. SMITH III 1 and GERALD R. CHRISTENSEN 1

1 Department of Ophthalmology, University of Texas Medical Branch, Galveston, Texas.

Assuming that fibrinolytic activity may play a role in cases of recurrent bleeding in traumatic hyphema, a microassay method for determining fibrinolytic activity in the aqueous humor was developed. Results indicate that the rabbit aqueous contains relatively low levels of fibrinolysin and high levels of fibrinolysin activators. Systemic administration of acetylsalicylic acid in therapeutic doses is shown to reduce the fibrinolytic activity in the aqueous of the rabbit substantially.

Note:
Junior Student, University of Texas Medical Branch.

Key Words: aqueous humor • fibrinolysin • fibrinolysin activators • acetylsalicylic acid • aspirin • salicylates • profibrinolysin • rabbit • hyphema

Submitted on December 1, 1970
Accepted on February 8, 1971






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Copyright © 1971 by the Association for Research in Vision and Ophthalmology