IOVS British Journal of Pharmacology
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(Investigative Ophthalmology and Visual Science. 1971;10:270-273.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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Ocular Hypertensive Response Following Acid and Alkali Burns in Rabbits

TZU SUNG CHIANG 1, LARRY R. MOORMAN 1, and ROBERT P. THOMAS 1

1 Division of Ophthalmology, Medical College of Georgia, Augusta, Ga.

Topical administration of hydrochloric acid, sodium hydroxide, and ammonium hydroxide produced a sustained dose-related rise in the intraocular pressure in rabbits. The ocular hypertensive response to sodium hydroxide consisted of a rapid initial rise followed by a gradual second rise. A quaitatively similar response with a smaller secondary rise was observed with the ammonium hydroxide burn. The response to hydrochloric acid was gradual in onset and was maximal within ten to 30 minutes after administration. At the highest concentration tested (2N) the ocular hypertensive responses to sodium hydroxide and hydrochloric acid persisted for three hours.

Key Words: intraocular pressure • ocular acid burn • ocular alkali burn • ocular hypertension

Submitted on January 20, 1971
Accepted on February 22, 1971






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Copyright © 1971 by the Association for Research in Vision and Ophthalmology