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(Investigative Ophthalmology and Visual Science. 1971;10:357-366.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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Activators and Inhibitors of Lens Aldose Reductase

J. A. JEDZINIAK 1 and J. H. KINOSHITA 1

1 Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Mass.

Aldose reductase in a highly purified state is unstable. It requires the presence of thiol groups to maintain it in an active form. The enzyme apparently exists in 3 forms, only one of which is active. Tetramethylene glutaric acid (TMG) is an effective aldose reductase inhibitor. However, a relatively high level of TMG is needed to depress dulcitol synthesis in the lens incubated in a galactose containing medium. TPN+, a product of the reaction, also inhibits the enzyme. The action of these inhibitors appears to transform the active into inactive enzyme.

Key Words: aldose reductase • aldose reductase inhibitor • tetramethylene gliitaric acid • sugar cataracts • lens enzyme

Submitted on March 3, 1971
Accepted on March 24, 1971




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W. Williams and J. Odom
Study of aldose reductase inhibition in intact lenses by 13C nuclear magnetic resonance spectroscopy
Science, July 11, 1986; 233(4760): 223 - 225.
[Abstract] [PDF]


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