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(Investigative Ophthalmology and Visual Science. 1971;10:415-423.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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Ultramicroscopic Changes in the Corneal Graft Stroma During Early Rejection

ATSUSHI KANAI 1 and FRANK M. POLACK 1

1 Department of Ophthalmology, College of Medicine, University of Florida Gainesville, Fla.

Early rejection of corneal stroma of penetrating homografts demonstrates various degrees of keratocyte degeneration. The altered cells are almost always in contact with small round or oval-shaped lymphocytes. Stromal changes are more pronounced in areas adjacent to epithelial or endothelial rejection. Lymphocytes, plasma cells, macrophages, and immunoblasts are present in large numbers at the host stroma or around limbal vessels where they seem to accumulate and replicate.

Note:
Reprint requests: Dr. Frank M. Polack, Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Fla. 32601.

Key Words: penetrating corneal transplants • graft rejection • skin grafts • corneal stroma • lymphocytes • immunoblasts • plasma cell • keratocytes histopathology • electron microscopy • light microscopy • rabbits

Submitted on March 16, 1971
Accepted on April 12, 1971






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Copyright © 1971 by the Association for Research in Vision and Ophthalmology