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(Investigative Ophthalmology and Visual Science. 1971;10:424-429.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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"Steroid-Induced" Mydriasis and Ptosis

DAVID A. NEWSOME 1, VERNON G. WONG 1, THOMAS P. CAMERON 2, and RICHARD R. ANDERSON 1

1 Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md. 20014
2 Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md. 20014

Pupil size, width of palpebral fissure, and intraocular pressure were followed in rhesus monkeys monkeys before and after treatment of one eye with dexamethasone phosphate in a vehicle mixture (Decadron), the vehicle mixture alone, some individual constituents of the vehicle, and pure steroid--dexamethasone in saline. Decadron and the vehicle alone produced relative pupillary dilation and ptosis, but dexamethasone in saline did not. Pupil and lid changes were not accompanied by a rise in intraocular pressure. The mydriasis and ptosis appeared to be caused by a direct myopathic effect of the vehicle.

Key Words: pupil size • palpebral fissure width • intraocular pressure • dexamethasone phosphate • ptosis • mydriasis • myopathy

Submitted on March 22, 1971
Accepted on April 30, 1971






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