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(Investigative Ophthalmology and Visual Science. 1971;10:489-495.)
© 1971 by The Association for Research in Vision and Ophthalmology, Inc.

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Chorioretinal Diffusion of Peroxidase Before and After Photocoagulation

GHOLAM A. PEYMAN 1, MANFRED SPITZNAS 1, and BRADLEY R. STRAATSMA 1

1 Department of Ophthalmology and Jules Stein Eye Institute, UCLA School of Medicine Los Angeles, Calif. 90024.

To study chorioretinal diffusion mechanisms in the mammalian retina, the peroxidase tracer technique, electron microscopy, and photocoagulation were used in a series of Dutch rabbits. Xenon arc photocoagulation of the retina was carried out on one eye of each animal, and three weeks later peroxidase was injected into the ear vein. At selected time intervals thereafter, the animals were killed, and the eyes were processed for electron microscopy. In the nonphotocoagulated eyes, tracer material diffused rapidly from the choriocapillaris, passed through Bruch's membrane, filled the basal infoldings of the pigment epithelium, and extended into the intercellular space between the pigment epithelium cells until it was stopped at the external margin of the zonulae occludentes. In the photocoagulated retina, peroxidase passed from the choroid, extended through Bruch's membrane, and diffused through the intercellular spaces of the external scar cells. Although there was no evidence of a zonula occludens-type junction, no tracer material was observed close to or central to the internal limiting membrane during this study. Consideration is given to the physiologic implications of these observations and to the mechanisms of action of photocoagulation in certan retinal diseases.

Note:
Reprint requests to: Gholam A. Peyman, M.D., Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, 1855 West Taylor Street, Chicago, Ill. 60612.

Key Words: chorioretinal diffusion • peroxidase tracer technique • electron microscopy • photocoagulation

Submitted on May 7, 1971
Accepted on June 8, 1971




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