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(Investigative Ophthalmology and Visual Science. 1972;11:822-831.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Retrocorneal Fibrous Membrane

RONALD G. MICHELS 1, KENNETH R. KENYON 1, and A. EDWARD MAUMENEE 1

1 Eye Pathology Laboratory of the Wilmer Institute, The Johns Hopkins University School of Medicine Baltimore, Md., Laboratory of Vision Research, National Eye Institute and National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.

Retrocorneal fibrous membranes were produced experimentally in rabbits by inducing endothelial cell damage with repeated transcorneal freezings and anterior segment inflammation. These membranes were reproducibly obtained without disrupting Descemet's membrane, and it was concluded that the stromal keratocyte did not participate in membrane formation. Light and electron microscopic study strongly suggested that the cellular and extracellular components of the retrocorneal membrane were derived from metaplastic endothelium.

Key Words: retrocorneal fibrous membrane • homograft reaction • penetrating keratoplasty • cornea • endothelial cell • transcomeal freezing • electron microscopy • metaplasia

Submitted on June 9, 1972
Accepted on August 21, 1972




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