IOVS Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 1972;11:832-837.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BIGGER, J. F.
Right arrow Articles by BECKER, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BIGGER, J. F.
Right arrow Articles by BECKER, B.

Increased Cellular Sensitivity to Glucocorticoids in Primary Open-Angle Glaucoma

JOHN F. BIGGER 1, PAUL F. PALMBERG 1, and BERNARD BECKER 1

1 Department of Ophthalmology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Mo. 63110.

When compared to nonglaucomatous control subjects, patients with primary open-angle glaucoma were found to have an increased sensitivity to glucocorticoids at the cellular level. Glucocorticoid sensitivity was evaluated in vitro by determining the concentration of prednisolone-21-phosphate necessary to inhibit by 50 per cent (I50) the uptake of tritriated thymidine into DNA during lymphocyte transformation induced by phytohemagglutinin-P. Mean I50 was 32 ng. per milliliter for 11 patents with primary open-angle glaucoma, compared to 65 ng. per milliliter for 10 control patients known to be ocular nonresponders to topical dexamethasone. A mean I50 of 44 ng. per milliliter was found for 6 nonglaucomatous persons who were highintraocular-pressure responders to topical dexamethasone, with a distribution of I50 values similar to that of the glaucoma patients. It is postulated that an increased receptor affinity for glucocorticoid may play a role in the etiology of open-angle glaucoma.

Key Words: glaucoma • open-angle • glucocorticoids • steroids • intraocular pressure • lymphocyte transformation • phytohemagglutinin

Submitted on May 17, 1972
Accepted on July 10, 1972




This article has been cited by other articles:


Home page
 IOVSHome page
J. Stokes, B. R. Walker, J. C. Campbell, J. R. Seckl, C. O'Brien, and R. Andrew
Altered Peripheral Sensitivity to Glucocorticoids in Primary Open-Angle Glaucoma
Invest. Ophthalmol. Vis. Sci., December 1, 2003; 44(12): 5163 - 5167.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B Becker, D. Shin, P. Palmberg, and Waltman SR
HLA antigens and corticosteroid response
Science, December 24, 1976; 194(4272): 1427 - 1428.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1972 by the Association for Research in Vision and Ophthalmology