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(Investigative Ophthalmology and Visual Science. 1972;11:838-844.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Local Ganglion-Like Stimulating Properties of Some Adrenergic Amines Which Affect Blood Vessels of the Anterior Segment of the Eye

FRANK J. MACRI 1

1 Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education, and Welfare Bethesda, Md. 20014.

L-Norepinephrine produced vasoconstriction in the anterior segment of the enucleated, arterially perfused cat eye by a mechanism compatible with {alpha}-adrenergic postganglionic stimulation. L-Epinephrine and D,L-isoproterenol also produced vasoconstriction, but unlike the response obtained with L-norepinephrine, the activity of these agents could be completely inhibited by either hexamethonium or atropine as well as by tolazoline. It is suggested that L-epinephrine and D,L-isoproterenol produce their response by stimulation of local sympathetic ganglion-like receptors.

Submitted on May 5, 1972
Accepted on August 18, 1972






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