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(Investigative Ophthalmology and Visual Science. 1972;11:850-856.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Lymphocytic Choriomeningitis Virus-Induced Retinopathy in Newborn Rats

ANDREW A. MONJAN 1, ARTHUR M. SILVERSTEIN 1, and GERALD A. COLE 1

1 Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, and The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Md.

Lymphocytic choriomeningitis virus has been found to produce a destructive retinopathy following intracerebral inoculation into the newborn rat. The progressive development of this pathology was seen, first, as a disorganization of the outer nuclear receptor layer, then as a loss of cells in the inner nuclear and ganglion cell layers and, finally, the total disorganization and destruction of the retina. The direct fluorescent antibody technique was used to trace the distribution of viral antigen during the development of the lesion. Virus icas detected, first, in the optic nerve and inner nuclear layer, then in the pigment epithelium, and finally, in all layers of the retina. Pathologic changes occurred in the outer nuclear layer prior to evidence of infection in those cells, suggesting that the disorganization might have been secondary to inapparent alteration of the infected pigment epithelium. Notwithstanding the widespread destruction of the retina, there was only a modest degree of inflammatory cell infiltrate. Preliminary experiments involving immunosuppression suggest that this retinal disease of the newborn rat may be mediated by immunopathologic mechanisms, a possibility which is currently under investigation.

Note:

c/o Dr. Mogens Volkert, Institute of Medical Microbiology, University of Copenhagen, 22 Juliane Maries Vej, DK-2100, Copenhagen Ø, Denmark.

Key Words: lymphocytic choriomeningitis virus • retinopathy • newborn rats • intraocular disease • viral etiology • pathogenesis • histopathology • immunofluorescence

Submitted on July 3, 1972
Accepted on July 20, 1972




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J. Chen and J. Nathans
Genetic Ablation of Cone Photoreceptors Eliminates Retinal Folds in the Retinal Degeneration 7 (rd7) Mouse
Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2799 - 2805.
[Abstract] [Full Text] [PDF]


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