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(Investigative Ophthalmology and Visual Science. 1972;11:890-893.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Tetrahydrotriamcinolone and Triamcinolone

I. Ocular Penetration

JOEL SUGAR 1, RONALD M. BURDE 1, ALAN SUGAR 1, STEPHEN R. WALTMAN 1, K. J. KRIPALANI 1, IRVING WELIKY 1, and BERNARD BECKER 1

1 Department of Ophthalmology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Mo. 63110, and the Squibb Institute for Medical Research, New Brunswick, N.J.

Triamcinolone (TA) and tetrahydrotriamcinolone (THTA) are very similar in structure, but only one, TA, consistently raises intraocular pressure in susceptible individuals. It has been postulated that these differences are due to differing penetration qualities. In the present study, using anterior chamber paracentesis in human eyes, these drugs were very similar in ocular penetration.

Key Words: triamcinolone • tetrahyclrotriamcinolone • drug penetration • corticosteroid-induced glaucoma • anterior chamber paracentesis

Submitted on June 29, 1972
Accepted on August 30, 1972






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