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(Investigative Ophthalmology and Visual Science. 1972;11:894-896.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Tetrahydrotriamcinolone and Triamcinolone

II. Effect on Xenograft Reaction in Rabbits

JOEL SUGAR 1, ALAN SUGAR 1, and RONALD M. BURDE 1

1 Department of Ophthalmology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Mo. 63110.

Triamcinolone (TA) and tetrahydrotriamcinolone (THTA) are similar in structure and ocular penetration capabilities but differ markedly in pressure-elevating potential in susceptible individuals. The present study, using pig-corneal xenograftsin rabbits, showed a small effect in preventing rejection using 0.25 per cent THTA, while 0.25 per cent TA and 0.001 per cent dexamethasone phosphate were effective.

Key Words: triamcinolone • tetrahydrotriamcinolone • dexamethasone • ocular inflammation • corticosteroid-induced glaucoma • xenograft

Submitted on June 29, 1972
Accepted on August 30, 1972






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