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(Investigative Ophthalmology and Visual Science. 1972;11:916-925.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Quantitative Ultrastructure of Capillaries in the Rat Retina

LEO SOSULA 1, PAUL BEAUMONT 2, KEITH M. JONSON 3, and FREDERICK C. HOLLOWS 2

1 Department of Neurobiology, Research School of Biological Sciences, Australian National University, Canberra, A.C.T., 2601.
2 Division of Ophthalmology, University of New South Wales, Randwick, N.S.W., 2031.
3 Department of Psychology, University of Sydney, N.S.W., 2006.

The quantitative ultrastructure of capillaries in the rat retina was studied in order to establish control parameters for experimentally induced vascular disorders. A near perfect correlation teas found between the number of tight junctions and the mean lumen area of retinal capillaries. Comparisons between female pigmented and albino rats of the same age showed no significant differences in all parameters measured. In contrast, comparisons between the nerve fiber layer, inner plexiform layer, and outer plexiform layer within the groups showed significant differences in the mean cross-section area, lumen area, cytoplasmic area of endothelial and mural cells, and basement membrane thickness. Light microscopic studies of araldite-embedded tissue showed a highly significant difference in the frequency of capillaries per unit area between retinal layers; approximately one half of the total number of retinal capillaries occurs in the outer plexiform layer of this species. Since the variability between retinal layers is greater than the variability between animals and between different strains, care should be taken to restrict comparisons to capillaries of the same retinal layer in control and experimental animals. Variation due to differences in the number of tight functions can be minimized by restricting comparisons to capillaries with the same number of functions.

Key Words: rat retina • capillaries • quantitative ultrastructure • normal parameters • tight junctions • lumen size • high correlation

Submitted on May 31, 1972
Accepted on August 25, 1972




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