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(Investigative Ophthalmology and Visual Science. 1972;11:1022-1027.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Prostaglandin E1 and Aqueous Humor Dynamics

MICHAEL A. KASS 1, STEVEN M. PODOS 1, ROBERT A. MOSES 1, and BERNARD BECKER 1

1 Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.

Topical administration of prostaglandin E1 (PGE1) produced a rise in intraocular pressure in intact eyes of awake rabbits. Tonography revealed an increased facility of outflow simultaneous with the elevation of intraocular pressure. Anterior chamber aqueous protein was higher and anterior chamber aqueous ascorbate was lower in eyes topically treated with PGE1 as compared to the untreated fellow eyes. A consensual elevation of intraocular pressure was noted in the fellow eye of those treated with PGE1.

Key Words: prostaglandin E1 • intraocular pressure • facility of outflow

Submitted on August 16, 1972
Accepted on September 22, 1972






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