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(Investigative Ophthalmology and Visual Science. 1972;11:1028-1036.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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In vivo Effects of Air and Sulfur Hexafluoride Gas on Rabbit Corneal Endothelium

DIANE L. VAN HORN 1, HENRY F. EDELHAUSER 1, THOMAS M. AABERG 1, and HARLAN J. PEDERSON 1

1 Departments of Ophthalmology and Physiology, The Medical College of Wisconsin, Milwaukee, Wisc; Research Service, Veterans Administration Center, Wood (Milwaukee) Wisc.

Bubbles of air or sulfur hexafluoride (SF6) gas were injected into the anterior chamber of rabbit eyes. The air bubbles persisted for 1 to 3 days, gradually decreasing in size. The SF6 bubbles initially expanded and then gradually decreased in size over a period of 3 to 5 days. Slit-lamp biomicroscopy revealed an orange peel-like pattern on the posterior corneal surface overlying both the air and the SF6 bubbles. Electron microscopy showed that the clinical changes in the endothelium were due to thickened areas composed of multilayers of new cells and Descemet's membrane-like material. Following reabsorption of the bubbles, the orange peel-like pattern disappeared, the old endothelial cells degenerated, the new Descemet's membrane became incorporated into the old, and the new endothelial cells formed a monolayer covering the posterior surface.

Key Words: cornea • corneal endothelium • corneal guttata • Descemet's membrane • intraocular air • ocular toxicity • rabbits • sulfur hexafluoride • ultrastructure

Submitted on July 28, 1972
Accepted on September 15, 1972






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