IOVS Drug Metabolism and Disposition
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(Investigative Ophthalmology and Visual Science. 1972;11:122-125.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Viral-Induced Ocular Tumors in Chicks

D. M. WORTHEN 1 and C. MOSCOVICI 1

1 Research Service, Veterans Administration Hospital, and the Departments of Ophthalmology, Immunology, and Medical Microbiology, University of Florida Gainesville, Fla.

Address for reprints: D. M. Worthen, M.D., Veterans Administration Hospital, Gainesville, Fla. 32601.

MC-29, a virus of the avian letikosis group, has been found to cause ocular hemorrhage in 42 per cent of infected chicks. Twelve-day-old white Leghorn chick embryos were injected intravenously. Tumors in the eye were localized to the anterior uvea and presented in association with hyphema and enlargement of the eye. Some appeared to be metastatic from abdominal tumors, whereas others appeared to be primary endotheliomas.

Key Words: chick embryos • avian leukosis virus • endothelioma • light microscopy • hyphemia • buphthalmos • metastatic tumors

Submitted on December 10, 1971
Accepted on December 10, 1971






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