IOVS Clinical and Diagnostic Laboratory Immunology
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(Investigative Ophthalmology and Visual Science. 1972;11:137-148.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Studies on the Nature of the Privilege Enjoyed by Corneal Allografts

ALI A. KHODADOUST 1 and ARTHUR M. SILVERSTEIN 2

1 The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Md.; Department of Ophthalmology, Pahlavi University Medical School, Shiraz, Iran.
2 The Wilmer Institute, The Johns Hopkins University School of Medicine Baltimore, Md.

Reprint requests to The Johns Hopkins University School of Medicine, Baltimore, Md. 21205.

The orthotopic corneal allograft enjoys a degree of immunologic privilege due in part to the usual avascularity of the recipient bed. It has been demonstrated that the absence of vascularization interferes with both the afferent limb of host sensitization and, in the previously sensitized host, with the efferent limb of graft rejection. Even when vascularized, however, the graft may only inadequately sensitize the host. Data are presented illustrating such other peculiarities of corneal graft rejection as the leisurely rate at which the cornea may reject as compared with skin, the consequences for the rejection process of the absence of donor vascular endothelium, and the occasional sparing of one or another of the corneal cell layers during rejection.

Key Words: keratoplasty • corneal allograft • transplantation • privileged site • lamellar graft • penetrating graft

Accepted on February 7, 1972




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F. C. Figueiredo, S. M. Nicholls, and D. L. Easty
Corneal Epithelial Rejection in the Rat
Invest. Ophthalmol. Vis. Sci., March 1, 2002; 43(3): 729 - 736.
[Abstract] [Full Text] [PDF]


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