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(Investigative Ophthalmology and Visual Science. 1972;11:149-152.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Presence, Significance, and Inhibition of Lysosomal Proteoglycanases

STUART I. BROWN 1, CAROL W. HOOK 1, and MICHAEL P. TRAGAKIS 1

1 Department of Ophthalmology, New York Hospital-Cornell University Medical Center, New York, N. Y.

Reprint requests to: Stuart I. Brown, M.D. 525 East 68th Street, New York, N. Y. 10021.

Lysosomal lysates of polymorphonuclear leukocytes (PMNL) were found to reduce the viscosity of a solution of corneal proteoglycan at pH 7.3 and 3.5. This indicates that PMNL contain proteoglycanases that can operate inside and outside the cell. The effect of the lysates on the proteoglycan can be inhibited by the {alpha}2 macroglobulin fraction of serum.

Key Words: Lysosomal lysates • polymorphonuclear leukocytes • viscosity • corneal proteoglycan

Accepted on January 20, 1972






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