IOVS Circulation
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(Investigative Ophthalmology and Visual Science. 1972;11:182-188.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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The Influence of Polyinosinic-Polycytidylic Acid Complex on Experimental Acute Toxoplasmic Retinochoroiditis in Rabbits

ENDLIAM CHOWCHUVECH 1, MERCEDES WEISSENBACHER 1, GABRIEL SCHMUNIS 1, LEON SAWICKI 1, MILES A. GALIN 1, and SAMUEL BARON 1

1 Department of Ophthalmology of the New York Medical College New York, N. Y., and the United States Department of Health, Education, and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.

Since interferon has been noted to protect certain tissue cultures against Toxoplasma gondii infection, and in vivo ocular experiment utilizing a potent interferon inducer, polyinosinic-polycytidylic acid (In · Cn), was undertaken. Pigmented rabbits were infected subretinally with 2 µl (2,000 Toxoplasma gondii organisms) of either the Beverley or RH strain suspended in Hank's balanced salt solution. Therapy with In · Cn was initiated two and one-half hours prior to infection. Intravenous injection of In · Cn, either 500 µg per day for four days or 300 µg per day for ten days, provided a mild degree of protection against Toxoplasma gondii of the Beverley strain. A delay in the evolution of posterior polar lesions was also noted. However, when rabbits were infected with Toxoplasma gondii of the RH strain, no differences were noted between the treated and control animals.

Key Words: polyinosinic-polycytidylic acid • Toxoplasma gondii infection • acute toxoplasmic retinochoroiditis • interferon

Accepted on January 7, 1972






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