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(Investigative Ophthalmology and Visual Science. 1972;11:211-220.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

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Effect of Sympathetic Stimulation on Ocular Hemodynamics

MILTON BEST 1, SAMUEL MASKET 1, and ASHER ZEEV RABINOVITZ 1

1 Department of Ophthalmology, New York Medical College, Center for Chronic Disease, Bird S. Coler Hospital, Welfare Island, New York, N. Y.

Reprint requests to: Dr. Best, New York Medical College, Center for Chronic Disease, Bird S. Coler Hospital, Welfare Island, New York, N. Y. 10017.

Although previous studies have indicated that cervical sympathetic stimulation reduces ipsilateral ocular blood flow, the mechanism of this effect is not apparent because simultaneous measurements of alterations in vascular perfusion pressure to the eye were not obtained. In the present study, the effects of cervical sympathetic stimulation on ocular hemodynamics and systemic blood pressure were investigated in the rabbit and the cat to determine whether ocular blood flow was altered by an active process and uveal vasoconstriction or passively in response to alterations in vascular perfusion pressure. In the rabbit, cervical sympathetic stimulation induced a decrease in femoral, carotid, and ciliary artery blood pressure. There was a simultaneous decrease in uveal blood flow and a slight but probably insignificant reduction of uveal vascular resistance. When the common carotid artery teas ligated, distal carotid and ciliary artery blood pressure and uveal blood flow increased after sympathetic stimulation. In the cat, sympathetic stimulation increased femoral, carotid, and ciliary artery blood pressure. Anterior uveal blood flow increased simultaneously, although uveal vascular resistance was not significantly affected. These results indicate that alterations in uveal flow after cervical sympathetic stimulation occur passively in response to chnges in ocular vascular perfusion pressure.

Key Words: sympathetic stimulation • ocular hemodynamics • uveal blood flow • uveal vascular resistance • ciliary artery blood pressure • ciliary artery blood flow • vortex vein blood flow

Revised on February 28, 1972
Accepted on January 17, 1972




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