IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 1972;11:747-751.)
© 1972 by The Association for Research in Vision and Ophthalmology, Inc.

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ELLIS, P. P.
Right arrow Articles by DEITRICH, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ELLIS, P. P.
Right arrow Articles by DEITRICH, R. A.

Enzymatic Hydrolysis of Pilocarpine

PHILIP P. ELLIS 1, KATHRINE LITTLEJOHN 1, and RICHARD A. DEITRICH 1

1 Division of Ophthalmology and Department of Pharmacology, University of Colorado Medical Center, Denver

Enzymatic hydrolysis of pilocarpine by rabbit and human serum, ocular tissues, and liver was demonstrated. Within each species the enzyme concentration in ocidar tissues appeared highest in uveal and retinal tissues and lowest in the lens. The Michaelis-Menten constants (Km) for the pilocarpine inactivating enzyme was 6.04 ± 2.52 x 10-4 M. for rabbit serum and 4.63 ± 2.02 x 10-3 M. for human serum.

Key Words: pilocarpine • enzymatic hydrolysis • enzyme kinetics • rabbit serum • human serum • enzyme concentration • rabbit ocular tissues • human ocular tissues

Submitted on April 24, 1972
Accepted on June 12, 1972




This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
T. Endo, M. Ban, K. Hirata, A. Yamamoto, Y. Hara, and Y. Momose
Involvement of CYP2A6 in the Formation of a Novel Metabolite, 3-Hydroxypilocarpine, from Pilocarpine in Human Liver Microsomes
Drug Metab. Dispos., March 1, 2007; 35(3): 476 - 483.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1972 by the Association for Research in Vision and Ophthalmology