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(Investigative Ophthalmology and Visual Science. 1973;12:52-64.)
© 1973 by The Association for Research in Vision and Ophthalmology, Inc.

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Tissue culture of human retinal pigment epithelium

Jean Mannagh 1, Dharmendra V. Arya 1, and A. Ray Irvine Jr. 1

1 Estelle Doheny Eye Foundation, 272 S. Lake St., Los Angeles, Calif. 90057

Adult human retinal pigment epithelium has been enzymatically isolated and established in tissue culture. Primary cultures survived three to six months. Occasionally, cell lines spontaneously evolved from primary cultures. Melanin granules decreased with the age of the culture, became less pigmented but retained some characterstics of melanin-producing cells. Lipofuscin granules are present, but differ from lipofuscin of testicular origin. Mitotic activity is present throughout the life of the cultures

Key Words: retinal pigment epithelium • tissue culture • primary culture • cell line • mitosis • melanin granules • lipofuscin granules

Submitted on July 18, 1972
Accepted on September 21, 1972






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