IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 1973;12:267-279.)
© 1973 by The Association for Research in Vision and Ophthalmology, Inc.

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GAASTERLAND, D.
Right arrow Articles by GABELNICK, H. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GAASTERLAND, D.
Right arrow Articles by GABELNICK, H. L.

Studies of Aqueous Humor Dynamics in Man

III. Measurements in Young Normal Subjects Using Norepinephrine and Isoproterenol

DOUGLAS GAASTERLAND 1, CARL KUPFER 1, KARYN ROSS 1, and HENRY L. GABELNICK 1

1 Clinical Branch, National Eye Institute and the Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014

The short-term effects on aqueous humor flow dynamics of single doses of l-norepinephrine and d,l-isoproterenol, alone and combined, were studied in selected young, normal males. Norepinephrine reduced pseudofacility without significantly altering intraocular pressure, episcleral venous pressure, or true facility of outflow. The rate of flow of aqueous was increased. Isoproterenol reduced intraocular pressure and decreased aqueous flow without altering true facility of outflow or pseudofacility. Flow curves plotted for the isoproterenol data disclosed a pressure-independent pattern of flow reduction. The combination of norepinephrine with isoproterenol produced changes of the parameters of intraocular pressure similar to those previously observed after l-epinephrine. This study provides evidence that the acute effect of epinephrine in young, normal male subjects is flow reduction from beta-adrenergic stimulation combined with pseudofacility reduction from alpha-adrenergic stimulation.

Submitted on October 10, 1972
Accepted on January 11, 1973




This article has been cited by other articles:


Home page
 IOVSHome page
C.-W. Do, C.-W. Kong, and C.-H. To
cAMP Inhibits Transepithelial Chloride Secretion across Bovine Ciliary Body/Epithelium
Invest. Ophthalmol. Vis. Sci., October 1, 2004; 45(10): 3638 - 3643.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C.-W. Do, K. Peterson-Yantorno, C. H. Mitchell, and M. M. Civan
cAMP-activated maxi-Cl- channels in native bovine pigmented ciliary epithelial cells
Am J Physiol Cell Physiol, October 1, 2004; 287(4): C1003 - C1011.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
B'A. T. Gabelt, J. Gottanka, E. Lutjen-Drecoll, and P. L. Kaufman
Aqueous Humor Dynamics and Trabecular Meshwork and Anterior Ciliary Muscle Morphologic Changes with Age in Rhesus Monkeys
Invest. Ophthalmol. Vis. Sci., May 1, 2003; 44(5): 2118 - 2125.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1973 by the Association for Research in Vision and Ophthalmology