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(Investigative Ophthalmology and Visual Science. 1973;12:603-607.)
© 1973 by The Association for Research in Vision and Ophthalmology, Inc.

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Increased Sensitivity to Theophylline Associated with Primary Open-Angle Glaucoma

HARRY A. ZINK 1, PAUL F. PALMBERG 1, and JOHN F. BIGGER 1

1 Department of Ophthalmology, Washington University School of Medicine 660 S. Euclid Ave., St. Louis, Mo. 63110

It has previously been reported that lymphocytes from patients with primary open-angle glaucoma and glucocorticoid-induced ocular hypertension demonstrate an increased sensitivity to glucocorticoids in vitro. Using the same in vitro assay we have studied the response of the lymphocyte to theophylline. When compared to nonglaucomatous control subjects, the lymphocytes from patients with primary open-angle glaucoma and glucocorticoid-induced ocular hypertension demonstrated an increased sensitivity to theophylline (p < 0.001). The concentration of theophylline necessary to inhibit by 50 per cent the uptake of tritiated thymidine into DNA correlated closely with values obtained for prednisolone-21-phosphate (r = +0.748). The possibility that the increased glucocorticoid sensitivity present in lymphocytes may be mediated by cyclic AMP is discussed.

Key Words: open-angle glaucoma • intraocular pressure • lymphocyte transformation • theophylline • phytohemagglutinin • glucocorticoids • cyclic AMP






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