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(Investigative Ophthalmology and Visual Science. 1974;13:740-747.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Histochemical Evidence of Cyclic Nucleotide Phosphodiesterase in Photoreceptor Outer Segments

RICHARD M. ROBB 1

1 Department of Ophthalmology, Children's Hospital Medical Center and Harvard Medical School, Boston, Mass.

A histochemical demonstration of cyclic 3',5'-nucleotide phosphodiesterase in retinal photoreceptor outer segments is reported for the first time. The enzyme appears to be located on outer segment lamellae. It is not found in adjacent inner segment or nuclear regions. This histochemical localization is consistent with previously reported biochemical studies showing high phosphodiesterase activity in preparations of isolated rod outer segments.

Key Words: histochemistry • phosphodiesterase • cyclic nucleotide • cyclic AMP • retina photoreceptor outer segments

Submitted on March 11, 1974






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