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(Investigative Ophthalmology and Visual Science. 1974;13:101-106.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Autoregulation of Optic-Disk Oxygen Tension

J. TERRY ERNEST 1

1 Eye Research Laboratories, The Department of Ophthalmology, The University of Chicago, 950 E. 59 St., Chicago, Ill. 60637

A micro-oxygen sensor was used to monitor the optic-disk oxygen tension in vivo in the cat. The perfusion pressure of the eye, defined as the systemic arterial blood pressure minus the intraocular pressure, was decreased. This was accomplished both by lowering the systemic arterial blood pressure by increasing the expiratory resistance and by elevating the intraocular pressure. The result of lowering the pension pressure of the eye was an initial decrease in the optic-disk oxygen tension and then a return to normal within approximately one minute. This autoregulation of the optic-disk oxygen tension was decreased by hypoxia and eliminated by hypercapnia. It was concluded that this autoregulation is a physiologic adjustment for homeostasis of the optic-disk tissue.

Note:
Presented in part at the Annual Meeting of the Association of Research in Vision and Ophthalmology, Sarasota, Fla., May 5, 1973.

Key Words: oxygen tension • optic disk • autoregulation • micro-oxygen electrode • intraocular pressure • ocular hypertension • perfusion pressure • hypoxia • hypercapnia • cat

Submitted on August 2, 1973
Accepted on September 25, 1973




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