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(Investigative Ophthalmology and Visual Science. 1974;13:107-115.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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In Vitro Inhibition of Protein Synthesis in the Retinal Pigment Epithelium by Chloroquine

LEONARD M. GONASUN 1 and ALBERT M. POTTS 1

1 Eye Research Laboratories and the Department of Ophthalmology, University of Chicago, 950 E. 59 St., Chicago, Ill. 60637

There is substantial evidence that the primary structure involved in chloroquine retinopathy is the retinal pigment epithelium (RPE) and that this drug, like the phenothiazines, stores in RPE in high concentration. Experiments reported here show that in concentrations of approximately 5 x 10-4M chloroquine inhibits protein synthesis in RPE without inhibiting amino acid uptake as measured with 14C-labeled phenylalanine, lysine, and leucine. Similar effects are observed with hydroxychloroquine, desethylchloroquine, and quinine. These findings strongly suggest that after storage in RPE the direct toxic effect of the drug is inhibition of protein synthesis.

Note:
A preliminary version of this paper was presented at the Fifth International Congress on Pharmacology, San Francisco, Calif., July 23 through 28, 1972.

Key Words: Chloroquine • desethylchloroquine • hydroxychloroquine • inhibition • melanin • photoreceptor • protein synthesis • retinal pigment epithelium • retinopathy

Submitted on June 25, 1973
Accepted on September 25, 1973




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A S Neubauer, K Samari-Kermani, U Schaller, U Welge-Lussen, G Rudolph, and T Berninger
Detecting chloroquine retinopathy: electro-oculogram versus colour vision
Br. J. Ophthalmol., July 1, 2003; 87(7): 902 - 908.
[Abstract] [Full Text] [PDF]


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