IOVS AJP: Cell Physiology
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(Investigative Ophthalmology and Visual Science. 1974;13:127-134.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Effects of Near UV Light Photoproducts of Epinephrine on Aqueous Humor Proteins

SEYMOUR ZIGMAN 1

1 University of Rochester School of Medicine and Dentistry, 260 Crittenden Blvd., Rochester, N. Y. 14642

At a level of 0.01 per cent in isolated, pooled calf aqueous humor, epinephrine bitartrate is converted into a series of pigmented. photoproducts by exposure to near UV light for only a few hours. The brown photoproducts, but not adrenochrome, bind to and alter the electrophoretic mobility of aqueous-humor proteins. The rapidity and mild conditions required for the above-described effects to occur, and other considerations of possible near UV photoproduct cellular toxicity, emphasize a need for physical or chemical measures to prevent near UV light exposure of the aqueous humor in patients treated with epinephrine, especially in the aphakic eye.

Key Words: epinephrine • near UV light • aqueous humor • protein electrophoretic mobility • ocular toxicity • photoproducts

Submitted on August 3, 1973
Accepted on September 12, 1973






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Copyright © 1974 by the Association for Research in Vision and Ophthalmology