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(Investigative Ophthalmology and Visual Science. 1974;13:153-155.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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The Arterial Pressure Dependency of the Increased Aqueous Humor Formation Induced by Ach+eserine

FRANK J. MACRI 1, STANLEY J. CEVARIO 1, and ELMER J. BALLINTINE 1

1 Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014

The magnitude of the increased rate of formation of aqueous humor produced by Ach+eserine is dependent and proportional to the arterial perfusate head pressure. Because of this, it may be assumed that the mechanism of the Ach+eserine response is due to an increase in ultrafiltration. It is suggested that the increase in ultrafiltration is brought about by a constriction of efferent ciliary process blood vessels.

It has recently been reported that the administration of acetylcholine plus eserine (Ach+eserine) to enucleated, arterially perfused cat eyes produces a marked increase in the rate of aqueous humor formation.1 The present study was undertaken to determine the vascular pressure dependency of this increased aqueous humor formation rate.

Submitted on October 19, 1973






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Copyright © 1974 by the Association for Research in Vision and Ophthalmology