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(Investigative Ophthalmology and Visual Science. 1974;13:235-237.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Fenoprofen and Ocular Prostaglandin Production

STEVEN M. PODOS 1 and BERNARD BECKER 1

1 Department of Ophthalmology, Washington University School of Medicine, St. Louis, Mo.

The ocular effect of fenoprofen, a new nonsteroidal anti-inflammatory agent, was studied. The elevations of intraocidar pressure and aqueous humor protein induced by 5 per cent arachidonic acid applied to rabbit eyes were partially blocked by topical pretreatment with 2 per cent fenoprofen. Fenoprofen 2 per cent did not prevent the elevation of intraocular pressure produced by 3 µg of prostaglandin Et. The results implied that fenoprofen inhibits the in vivo synthesis or release of ocular prostaglandin.

Key Words: fenoprofen • nonsteroidal anti-inflammatory agent • prostaglandin synthesis

Submitted on December 20, 1973







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