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(Investigative Ophthalmology and Visual Science. 1974;13:280-287.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Experimental Ocular Irradiation with Accelerated Protons

IAN J. CONSTABLE 1 and ANDREAS M. KOEHLER 2

1 Department of Retina Research, Retina Foundation, Boston, and the Department of Physics, Harvard University, Cambridge, Mass.
2 Department of Retina Research, Retina Foundation, Boston, and the Department of Physics, Harvard University Cambridge, Mass.

High-energy proton beams of 7 mm. diameter or less were used to irradiate monkey eyes. When the Bragg peak was positioned immediately in front of the retina, it was possible to apply an acute radiation burn to a discrete area of the retina and choroid while delivering much smaller doses to other ocular and orbital tissues. The minimal scatter, finite penetration, and advantageous dose-distribution curve for soft tissues make this mode of radiotherapy very attractive for the treatment of ocular and orbital tumors.

Note:
Presented in part at the meeting of the Association for Research in Vision and Ophthalmology, Birmingham, Ala., Nov. 1, 1973.

Key Words: irradiation • retina • protons • Bragg peak • dosimetry • stereotaxis • cyclotron

Submitted on December 28, 1973




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