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(Investigative Ophthalmology and Visual Science. 1974;13:288-290.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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The Vitamin A Transporting Protein Complex in Human Hereditary Pigmentous Retinal Dystrophy

G. MARAINI 1

1 University Eye Clinic, 43100 Parma, Italy

Highly purified preparations of prealbumin-retinal-binding protein complex (PA-RBP), prealbumin (PA), and retinol-binding protein (RBP) have been isolated from the plasma of patients with inherited retinitis pigmentosa and compared with the same proteins obtained from normal human plasma. On the basis of absorption and fluorescence characteristics, polarization fluorescence measurements at low and physiologic ionic strength, and chromatographic behavior it is concluded that no evidence has been obtained that retinitis pigmentosa RBP differs from normal RBP in its ability to interact with PA or in its capacity to act as a carrier of retinol.

Key Words: thyroxine-binding prealbumin • retinol-binding • protein • retinol • pigmentous retinal degeneration

Submitted on November 7, 1973






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