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(Investigative Ophthalmology and Visual Science. 1974;13:302-304.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Adenine Arabinoside Effect on Experimental Idoxuridine-Resistant Herpes Simplex Infection

ANTHONY B. NESBURN 1, CHRISTINE ROBINSON 1, and RANDOLPH DICKINSON 1

1 Estelle Doheny Eye Foundation Laboratory, 272 S. Lake St., Los Angeles, Calif. 90057.

Topical application of idoxuridine (IDU) is presently a standard treatment for epithelial herpes simplex keratitis in man. While IDU therapy is usually satisfactory, clinically resistant keratitis has been encountered. In most instances, the actual basis of these IDU treatment failures is never determined. On occasion, viral isolates from such cases have proved to be biochemically resistant to IDU.1 An important attribute for any new antiherpes drug would be its ability to successfully manage cases in which IDU failed clinically, including those in which the infecting virus was biochemically resistant to IDU.

Key Words: IDU-resistant herpes simplex virus • keratitis • adenine arabinoside

Submitted on December 4, 1973




This article has been cited by other articles:


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A. B. Nesburn, S. Slanina, R. L. Burke, H. Ghiasi, S. Bahri, and S. L. Wechsler
Local Periocular Vaccination Protects against Eye Disease More Effectively Than Systemic Vaccination following Primary Ocular Herpes Simplex Virus Infection in Rabbits
J. Virol., October 1, 1998; 72(10): 7715 - 7721.
[Abstract] [Full Text] [PDF]


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