IOVS Journal of Pharmacology and Experimental Therapeutics
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(Investigative Ophthalmology and Visual Science. 1974;13:316-319.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Prednisolone Phosphate Penetration into and Through the Cornea

KEITH GREEN 1 and SUSAN J. DOWNS 1

1 W. K. Kellogg Research Laboratories, The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Md.

The penetration of labeled prednisolone phosphate into the aqueous humor and cornea of rabbits was measured at times up to six hours after the addition of one drop to the cornea in various vehicles. Adsorbobase produced a marked increase in both corneal and aqueous humor content over sodium chloride solution. Benzalkonium chloride (0.01 per cent) increased the penetration of prednisolone in Adsorbobase but not in sodium chloride solution. The use of benzalkonium chloride as a preservative in vehicles which increase corneal retention time appears to be contraindicated in steroid preparations.

Key Words: steroids • prednisolone phosphate • vehicle • benzalkonium chloride • aqueous humor • cornea • rabbit

Submitted on December 17, 1974






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