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(Investigative Ophthalmology and Visual Science. 1974;13:340-361.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Retinal Synaptogenesis in the Primate

GEORGE K. SMELSER 1, VICTORIA OZANICS 1, MARY RAYBORN 1, and DIGNA SAGUN 1

1 Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, N. Y. 10032

Morphologic observations on early retinal synaptogenesis of Macaca mulatta fetuses of known gestational ages are described. Attempt is made to correlate the first appearance of synaptic vesicles, lamellar material, and the establishment of presynaptic contacts in both the inner and outer plexiform layers and in both types of synapses developing in these zones. Possible origin of lamellar material and synaptic vesicles are postulated, based on morphologic evidence derived from electron micrographs. Attention was focussed on fetal gestational stages from the earliest appearance of the outer plexiform layer to past midterm in gestation, just prior to the development of outer segment discs. Synaptic connections occurred in both layers nearly simultaneously and before the appearance of outer segment discs. Cone synaptogenesis preceded that of rods.

Note:
Public Health Service Research Career Program Award No. 5K06 EY 19609-10 from the National Eye Institute.

Key Words: retina • primate • synapses • synaptic vesicles • synaptic ribbons • inner plexiform layer • outer plexiform layer • rods • cones

Submitted on January 21, 1974




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