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(Investigative Ophthalmology and Visual Science. 1974;13:362-368.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Studies on Intravitreal Blood Vessels. I. A New Experimental Model

DONALD R. SANDERS 1 and GHOLAM A. PEYMAN 1

1 Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, University of Illinois at the Medical Center, Chicago, Ill.

We produced an experimental animal model simulating intravitreal neovascularization by injecting 0.1 ml. of a solution containing 15 mg. of ammonium chloride (NH4Cl) into the vitreous cavity of albino rabbits. This dosage causes exudative retinal detachment, destruction of the retina, liquefaction of the vitreous, contraction of the posterior hyaloid membrane, and only minimal retinal vessel damage. Contraction of the posterior hyaloid membrane draws the retinal vessels into the mid-vitreous cavity. The intravitreally displaced retinal vessels provide an excellent model for evaluation of treatment modalities for intravitreal neovascularization.

Key Words: experimental model • intravitreal neovascularization • ammonium chloride • exudative retinal detachment

Submitted on January 10, 1974






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