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(Investigative Ophthalmology and Visual Science. 1974;13:475-477.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Cyclic-AMP in Ocular Tissues of the Rabbit, Monkey, and Human

ARTHUR H. NEUFELD 1 and MARVIN L. SEARS 1

1 Department of Ophthalmology and Visual Science, Yale University School of Medicine, 333 Cedar St., New Haven, Conn. 06510

The ability of various ocular tissues to make cyclic-AMP and release it into the media has been determined. The posterior chamber contains little, if any, cyclic-AMP either before or after administration of epinephrine to the rabbit eye; therefore, neither the lens nor the ciliary body contributes to the aqueous humor of the anterior chamber, the cyclic-AMP which correlates with the intraocular pressure response. In vitro, tissues lining the anterior chamber such as the cornea, iris, and sclera-trabecular tissue make cyclic-AMP in response to various agonists and can release cyclic-AMP into the incubation media. Of particular interest, is the response of the sclera-trabecular tissue with contains the cells lining the channels for the outflow of aqueous humor. Cyclic-AMP in this tissue may play a role in the regulation of intraocular pressure.

Key Words: cyclic-AMP • cornea • iris • trabecular meshwork • anterior chamber • posterior chamber • adrenergic agonists

Submitted on September 22, 1973




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