IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 1974;13:550-554.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BROEKHUYSE, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BROEKHUYSE, R. M.

Tear Lactoferrin: A Bacteriostatic and Complexing Protein

R. M. BROEKHUYSE 1

1 Department of Ophthalmology, University of Nijmegen, Nijmegen, The Netherlands

The presence of lactoferrin in human tears is established by immunochemical techniques. Together with tear pre-albumin, IgA, and lysozyme they constitute the major tear proteins. Lactoferrin added to tears binds to IgA, IgG, and serum albumin and alters their electrophoretic mobility. On agarose and agar gels it has a different electrophoretic behavior, which together with its complexing properties offers several possibilities for misinterpretation of immunochemical results. Lactoferrin has an apparent molecular weight of approximately 82,000 as established by dodecyl sulfate-polyacrylamide gel electrophoresis. It has bacteriostatic properties, presumably due to its ability to make certain metals unavailable for microorganisms.

Key Words: lactoferrin • tear proteins • immunoglobulins (tear) • immunoelectrophoresis (tear) • transferrin • antibacterial activity • tear lactoferrin • lactoferrin-protein complexes

Submitted on March 21, 1974






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1974 by the Association for Research in Vision and Ophthalmology