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(Investigative Ophthalmology and Visual Science. 1974;13:586-592.)
© 1974 by The Association for Research in Vision and Ophthalmology, Inc.

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Ocular Manifestations of Marek's Disease

THOMAS W. SMITH 1, DANIEL M. ALBERT 1, NANCY ROBINSON 1, BRUCE W. CALNEK 2, and OTTO SCHWABE 3

1 Department of Ophthalmology, Yale University School of Medicine, New Haven, Conn.
2 Department of Avian Diseases, New York State University College, Cornell University, Ithaca, N. Y.
3 N. Y. Rutgers Health Laboratory, Rutgers University, Vineland, N. J.

An experimental study of the ocular changes occurring in Marek's disease was carried out. Marek's disease which is induced by a DNA virus, is a disorder that occurs in chickens and related fowl. Ocular involvement is a feature of this disease. In this study the eye changes of Marek's disease were sequentially examined in specific, pathogen-free birds injected with clone purified Marek's disease virus. An infiltration of malignant-appearing lymphoreticular proliferative cells was seen initially in the optic nerves, ciliary nerves, and uvea in birds receiving the virus either intraocularly or systemically. Subsequent infiltration of similar cells occurred throughout the eye.

Key Words: ocular tumor • Marek's disease • avian herpesvirus • DNA virus • lymphoreticular proliferative disease • avian leukosis

Submitted on February 14, 1964






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